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Dosis inicial warfarina-acenocumarol. Algoritmo calculador
La mayoría de accidentes por hemorragia en el tratamiento con cumarínicos, ocurren dentro de los dos primeros meses de iniciar el tratamiento.
Ello se debe a que ante una dosis “estándar”, pacientes metabolizadores lentos para el CYP2C9 y/o el VKORC1, irán acumulando fármaco sin metabolizar, con altos niveles sanguíneos del fármaco, lo que producirá el efecto de sobredosis, con alto riesgo de sangrado.
Dosis inicial warfarina-acenocumarol. Algoritmo calculador
La mayoría de accidentes por hemorragia en el tratamiento con cumarínicos, ocurren dentro de los dos primeros meses de iniciar el tratamiento.
Ello se debe a que ante una dosis “estándar”, pacientes metabolizadores lentos para el CYP2C9 y/o el VKORC1, irán acumulando fármaco sin metabolizar, con altos niveles sanguíneos del fármaco, lo que producirá el efecto de sobredosis, con alto riesgo de sangrado.
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Initial dose warfarin-acenocoumarol. Calculating algorithm
Most bleeding accidents in coumarin treatment occur within the first two months of starting treatment.
This is due to the fact that at a “standard” dose, patients with slow metabolisers for CYP2C9 and / or VKORC1 will accumulate unmetabolized drug, with high blood levels of the drug, which will produce the effect of overdose, with a high risk of bleeding. .
Initial dose warfarin-acenocoumarol. Calculating algorithm
Most bleeding accidents in coumarin treatment occur within the first two months of starting treatment.
This is due to the fact that at a “standard” dose, patients with slow metabolisers for CYP2C9 and / or VKORC1 will accumulate unmetabolized drug, with high blood levels of the drug, which will produce the effect of overdose, with a high risk of bleeding. .
Dosis para acenocumarol
La dosis inicial recomendada para el acenocumarol es la mitad del calculo resultante para la warfarina
Inductores demostrado para: carbamazepina, fenitoína, rifampicina; sin embargo deben tenerse en cuenta otros fármacos inductores del CYP2C9.
ALGORITMO TOMADO DE:
The International warfarin Pharmacogenetics Consortium.
“Estimation of the warfarin dose with Clinical and Pharmacogenetic Data”.
The New England Journal of Medicine (2009); 360(8): 753-764.
La dosis inicial recomendada para el acenocumarol es la mitad del calculo resultante para la warfarina
Inductores demostrado para: carbamazepina, fenitoína, rifampicina; sin embargo deben tenerse en cuenta otros fármacos inductores del CYP2C9.
ALGORITMO TOMADO DE:
The International warfarin Pharmacogenetics Consortium.
“Estimation of the warfarin dose with Clinical and Pharmacogenetic Data”.
The New England Journal of Medicine (2009); 360(8): 753-764.
Dosage for acenocoumarol
The recommended starting dose for acenocoumarol is half the resulting calculation for warfarin
Inducers shown for: carbamazepine, phenytoin, rifampin; however, other CYP2C9 inducing drugs should be taken into account.
ALGORITHM TAKEN FROM:
The International warfarin Pharmacogenetics Consortium.
"Estimation of the warfarin dose with Clinical and Pharmacogenetic Data".
The New England Journal of Medicine (2009); 360 (8): 753-764.
The recommended starting dose for acenocoumarol is half the resulting calculation for warfarin
Inducers shown for: carbamazepine, phenytoin, rifampin; however, other CYP2C9 inducing drugs should be taken into account.
ALGORITHM TAKEN FROM:
The International warfarin Pharmacogenetics Consortium.
"Estimation of the warfarin dose with Clinical and Pharmacogenetic Data".
The New England Journal of Medicine (2009); 360 (8): 753-764.
FreeMarker template error!
Error reading included file templates/genes/templates/applicationPage.ftl The problematic instruction: ---------- ==> include def.mainArea.template [on line 374, column 21 in templating-kit/templates/main.ftl] ---------- Java backtrace for programmers: ---------- freemarker.template.TemplateException: Error reading included file templates/genes/templates/applicationPage.ftl at freemarker.core.Include.accept(Include.java:167) at freemarker.core.Environment.visit(Environment.java:210) at freemarker.core.MixedContent.accept(MixedContent.java:92) at freemarker.core.Environment.visit(Environment.java:210) at freemarker.core.Environment.process(Environment.java:190) at freemarker.template.Template.process(Template.java:237) at info.magnolia.freemarker.FreemarkerHelper.render(FreemarkerHelper.java:152) at info.magnolia.module.templating.renderers.FreemarkerTemplateRenderer.onRender(FreemarkerTemplateRenderer.java:74) at info.magnolia.module.templating.AbstractRenderer.render(AbstractRenderer.java:83) at info.magnolia.module.templatingkit.renderers.STKTemplateRenderer.render(STKTemplateRenderer.java:88) at info.magnolia.module.templating.renderers.AbstractTemplateRenderer.renderTemplate(AbstractTemplateRenderer.java:76) at info.magnolia.module.templating.engine.DefaultRenderingEngine$RenderingHelper$2.render(DefaultRenderingEngine.java:105) at info.magnolia.module.templating.engine.DefaultRenderingEngine.render(DefaultRenderingEngine.java:165) at info.magnolia.module.templating.engine.DefaultRenderingEngine.render(DefaultRenderingEngine.java:127) at info.magnolia.module.templating.engine.DefaultRenderingEngine$$EnhancerByCGLIB$$96193988.render(<generated>) at info.magnolia.module.templating.RenderingFilter.render(RenderingFilter.java:132) at info.magnolia.module.templating.RenderingFilter.doFilter(RenderingFilter.java:92) at info.magnolia.cms.filters.AbstractMgnlFilter.doFilter(AbstractMgnlFilter.java:70) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:82) at com.soluter.genes.SecurityFilter.doFilter(SecurityFilter.java:20) at info.magnolia.cms.filters.AbstractMgnlFilter.doFilter(AbstractMgnlFilter.java:70) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:82) at com.soluter.genes.LanguageRedirectFilter.doFilter(LanguageRedirectFilter.java:42) at info.magnolia.cms.filters.AbstractMgnlFilter.doFilter(AbstractMgnlFilter.java:70) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:82) at com.soluter.genes.SecureRedirectFilter.doFilter(SecureRedirectFilter.java:33) at info.magnolia.cms.filters.AbstractMgnlFilter.doFilter(AbstractMgnlFilter.java:70) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:82) at info.magnolia.cms.filters.BackwardCompatibilityFilter.doFilter(BackwardCompatibilityFilter.java:72) at info.magnolia.cms.filters.OncePerRequestAbstractMgnlFilter.doFilter(OncePerRequestAbstractMgnlFilter.java:62) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:82) at info.magnolia.cms.filters.InterceptFilter.doFilter(InterceptFilter.java:121) at info.magnolia.cms.filters.AbstractMgnlFilter.doFilter(AbstractMgnlFilter.java:70) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:82) at info.magnolia.cms.filters.AggregatorFilter.doFilter(AggregatorFilter.java:103) at info.magnolia.cms.filters.AbstractMgnlFilter.doFilter(AbstractMgnlFilter.java:70) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:82) at info.magnolia.cms.security.BaseSecurityFilter.doFilter(BaseSecurityFilter.java:61) at info.magnolia.cms.filters.AbstractMgnlFilter.doFilter(AbstractMgnlFilter.java:70) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:82) at info.magnolia.cms.filters.RepositoryMappingFilter.doFilter(RepositoryMappingFilter.java:90) at info.magnolia.cms.filters.AbstractMgnlFilter.doFilter(AbstractMgnlFilter.java:70) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:82) at info.magnolia.cms.filters.CompositeFilter.doFilter(CompositeFilter.java:64) at info.magnolia.cms.filters.AbstractMgnlFilter.doFilter(AbstractMgnlFilter.java:70) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:82) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:76) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:84) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:84) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:84) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:84) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:84) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:84) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:84) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:84) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:84) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:84) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:84) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:84) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:84) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:84) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:84) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:84) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:84) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:84) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:84) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:84) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:84) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:84) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:84) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:84) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:84) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:84) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:84) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:84) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:84) at info.magnolia.cms.filters.CompositeFilter.doFilter(CompositeFilter.java:64) at info.magnolia.cms.filters.AbstractMgnlFilter.doFilter(AbstractMgnlFilter.java:70) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:82) at info.magnolia.cms.filters.VirtualUriFilter.doFilter(VirtualUriFilter.java:130) at info.magnolia.cms.filters.AbstractMgnlFilter.doFilter(AbstractMgnlFilter.java:70) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:82) at info.magnolia.module.cache.executor.Bypass.processCacheRequest(Bypass.java:57) at info.magnolia.module.cache.filter.CacheFilter.doFilter(CacheFilter.java:123) at info.magnolia.cms.filters.OncePerRequestAbstractMgnlFilter.doFilter(OncePerRequestAbstractMgnlFilter.java:62) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:82) at info.magnolia.cms.i18n.I18nContentSupportFilter.doFilter(I18nContentSupportFilter.java:75) at info.magnolia.cms.filters.AbstractMgnlFilter.doFilter(AbstractMgnlFilter.java:70) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:82) at info.magnolia.module.cache.filter.GZipFilter.doFilter(GZipFilter.java:83) at info.magnolia.cms.filters.OncePerRequestAbstractMgnlFilter.doFilter(OncePerRequestAbstractMgnlFilter.java:62) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:82) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:84) at info.magnolia.cms.security.BaseSecurityFilter.doFilter(BaseSecurityFilter.java:61) at info.magnolia.cms.filters.AbstractMgnlFilter.doFilter(AbstractMgnlFilter.java:70) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:82) at info.magnolia.cms.security.LogoutFilter.doFilter(LogoutFilter.java:89) at info.magnolia.cms.filters.OncePerRequestAbstractMgnlFilter.doFilter(OncePerRequestAbstractMgnlFilter.java:62) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:82) at info.magnolia.cms.security.auth.login.LoginFilter.doFilter(LoginFilter.java:80) at info.magnolia.cms.filters.AbstractMgnlFilter.doFilter(AbstractMgnlFilter.java:70) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:82) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:84) at info.magnolia.cms.filters.CosMultipartRequestFilter.doFilter(CosMultipartRequestFilter.java:87) at info.magnolia.cms.filters.AbstractMgnlFilter.doFilter(AbstractMgnlFilter.java:70) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:82) at info.magnolia.cms.filters.ContentTypeFilter.doFilter(ContentTypeFilter.java:90) at info.magnolia.cms.filters.AbstractMgnlFilter.doFilter(AbstractMgnlFilter.java:70) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:82) at info.magnolia.cms.filters.ContextFilter.doFilter(ContextFilter.java:87) at info.magnolia.cms.filters.AbstractMgnlFilter.doFilter(AbstractMgnlFilter.java:70) at info.magnolia.cms.filters.MgnlFilterChain.doFilter(MgnlFilterChain.java:82) at info.magnolia.cms.filters.CompositeFilter.doFilter(CompositeFilter.java:64) at info.magnolia.cms.filters.AbstractMgnlFilter.doFilter(AbstractMgnlFilter.java:70) at info.magnolia.cms.filters.MgnlMainFilter.doFilter(MgnlMainFilter.java:96) at info.magnolia.cms.filters.MgnlMainFilter.doFilter(MgnlMainFilter.java:199) at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:246) at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:214) at org.apache.catalina.core.StandardWrapperValve.invoke(StandardWrapperValve.java:313) at org.apache.catalina.core.StandardContextValve.invokeInternal(StandardContextValve.java:287) at org.apache.catalina.core.StandardContextValve.invoke(StandardContextValve.java:218) at org.apache.catalina.core.StandardPipeline.doInvoke(StandardPipeline.java:648) at org.apache.catalina.core.StandardPipeline.doInvoke(StandardPipeline.java:593) at com.sun.enterprise.web.WebPipeline.invoke(WebPipeline.java:94) at com.sun.enterprise.web.PESessionLockingStandardPipeline.invoke(PESessionLockingStandardPipeline.java:98) at org.apache.catalina.core.StandardHostValve.invoke(StandardHostValve.java:222) at org.apache.catalina.core.StandardPipeline.doInvoke(StandardPipeline.java:648) at org.apache.catalina.core.StandardPipeline.doInvoke(StandardPipeline.java:593) at org.apache.catalina.core.StandardPipeline.invoke(StandardPipeline.java:587) at org.apache.catalina.core.ContainerBase.invoke(ContainerBase.java:1093) at org.apache.catalina.core.StandardEngineValve.invoke(StandardEngineValve.java:166) at org.apache.catalina.core.StandardPipeline.doInvoke(StandardPipeline.java:648) at org.apache.catalina.core.StandardPipeline.doInvoke(StandardPipeline.java:593) at org.apache.catalina.core.StandardPipeline.invoke(StandardPipeline.java:587) at org.apache.catalina.core.ContainerBase.invoke(ContainerBase.java:1093) at org.apache.coyote.tomcat5.CoyoteAdapter.service(CoyoteAdapter.java:291) at com.sun.enterprise.web.connector.grizzly.DefaultProcessorTask.invokeAdapter(DefaultProcessorTask.java:666) at com.sun.enterprise.web.connector.grizzly.DefaultProcessorTask.doProcess(DefaultProcessorTask.java:597) at com.sun.enterprise.web.connector.grizzly.DefaultProcessorTask.process(DefaultProcessorTask.java:872) at com.sun.enterprise.web.connector.grizzly.DefaultReadTask.executeProcessorTask(DefaultReadTask.java:341) at com.sun.enterprise.web.connector.grizzly.ssl.SSLReadTask.process(SSLReadTask.java:444) at com.sun.enterprise.web.connector.grizzly.ssl.SSLReadTask.doTask(SSLReadTask.java:230) at com.sun.enterprise.web.connector.grizzly.TaskBase.run(TaskBase.java:264) at com.sun.enterprise.web.connector.grizzly.ssl.SSLWorkerThread.run(SSLWorkerThread.java:106) Caused by: java.io.FileNotFoundException: Template templates/genes/templates/applicationPage.ftl not found. at freemarker.template.Configuration.getTemplate(Configuration.java:489) at freemarker.core.Environment.getTemplateForInclusion(Environment.java:1465) at freemarker.core.Include.accept(Include.java:157) ... 143 more